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首页> 外文OA文献 >A randomised controlled trial investigating the effects of Mediterranean diet and aerobic exercise on cognition in cognitively healthy older people living independently within aged care facilities: the Lifestyle Intervention in Independent Living Aged Care (LIILAC) study protocol [ACTRN12614001133628]
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A randomised controlled trial investigating the effects of Mediterranean diet and aerobic exercise on cognition in cognitively healthy older people living independently within aged care facilities: the Lifestyle Intervention in Independent Living Aged Care (LIILAC) study protocol [ACTRN12614001133628]

机译：一项随机对照试验，调查地中海饮食和有氧运动对老年护理机构内独立生活的认知健康老年人认知的影响：独立生活老年护理生活方式干预（LIILaC）研究方案[aCTRN12614001133628]

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Background The rapid ageing of the population is becoming an area of great concern, both globally and in Australia. On a societal level, the cost of supporting an ageing demographic, particularly with their associated medical requirements, is becoming an ever increasing burden that is only predicted to rise in the foreseeable future. The progressive decline in individuals' cognitive ability as they age, particularly with respect to the ever increasing incidence of Alzheimer's Disease (AD) and other cognitive complications, is in many respects one of the foundation stones of these concerns. There have been numerous observational studies reporting on the positive effects that aerobic exercise and the Mediterranean diet appear to have on improving cognitive ability. However, the ability of such interventions to improve cognitive ability, or even reduce the rate of cognitive ageing, has not been fully examined by substantial interventional studies within an ageing population. Methods The LIILAC trial will investigate the potential for cognitive change in a cohort of cognitively healthy individuals, between the ages of 60 and 90 years, living in independent accommodation within Australian aged care facilities. This four-arm trial will investigate the cognitive changes which may occur as a result of the introduction of aerobic exercise and/or Mediterranean diet into individuals' lifestyles, as well as the mechanisms by which these changes may be occurring. Participants will be tested at baseline and 6 months on a battery of computer based cognitive assessments, together with cardiovascular and blood biomarker assessments. The cardiovascular measures will assess changes in arterial stiffness and central pulse pressures, while the blood measures will examine changes in metabolic profiles, including brain derived neurotrophic factor (BDNF), inflammatory factors and insulin sensitivity. Conclusion It is hypothesised that exercise and Mediterranean diet interventions, both individually and in combination, will result in improvements in cognitive performance compared with controls. Positive findings in this research will have potential implications for the management of aged care, particularly in respect to reducing the rate of cognitive decline and the associated impacts both on the individual and the broader community. Trial registration Australia New Zealand Clinical Trial Registry-ACTRN12614001133628
机译：背景技术人口的快速老龄化正在成为全球和澳大利亚关注的一个领域。从社会的角度来看，支持老龄化人口的成本，尤其是与其相关的医疗需求有关的成本，正变得越来越重，仅在可预见的将来会增加。随着年龄的增长，个人认知能力的逐步下降，尤其是在阿尔茨海默氏病（AD）和其他认知并发症的发病率不断增加的方面，在许多方面都是这些关注的基石之一。有许多观察性研究报告了有氧运动和地中海饮食对提高认知能力的积极作用。但是，在老年人口中进行的大量干预研究尚未充分检验此类干预措施提高认知能力甚至降低认知老化率的能力。方法LIILAC试验将调查一群年龄在60至90岁之间，居住在澳大利亚老年护理设施中独立居住的认知健康个体的认知变化潜力。这项四臂试验将调查有氧运动和/或地中海饮食引入个人生活方式可能导致的认知变化，以及这些变化可能发生的机制。参与者将在基线和6个月时接受一系列基于计算机的认知评估以及心血管和血液生物标志物评估，接受测试。心血管措施将评估动脉僵硬度和中央脉搏压力的变化，而血液措施将评估代谢曲线的变化，包括脑源性神经营养因子（BDNF），炎性因子和胰岛素敏感性。结论假设运动和地中海饮食干预，无论是单独还是结合使用，与对照组相比，都会改善认知能力。这项研究的积极发现将对老年护理的管理产生潜在的影响，特别是在降低认知能力下降的速度以及对个人和整个社区的相关影响方面。试验注册澳大利亚新西兰临床试验注册中心-ACTRN12614001133628

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